Guidelines:

We love previously unpublished quirky writing that makes sense, preferably flash fiction (less than 1000 words). We are eager to read short creative nonfiction also. We rarely accept submissions that have over 2700 words. We enjoy poems that we understand, preferably not rhyming poems, unless you make the rhyme so fascinating we’ll wonder why we ever said anything about avoiding rhymes. Give us something fresh, unexpected, and will make us say, “Wow!” We’re not interested in homophobic, religious rants, or pornographic, violent stories.

We are always interested in publishing intriguing photography, artwork, and graphic (you know, comics) literature.   Send all artwork as jpg or gif.  We like to have at least three images.
Please wait one year to resubmit after we have published your work.
Please wait 60 days to resubmit after we have rejected your work.
More information about our guidelines are on Submittable.  

With his customary wisdom and wit, Kurt Vonnegut put forth 8 basics of what he calls Creative Writing 101:

1. Use the time of a total stranger in such a way that he or she will not feel the time was wasted.
2. Give the reader at least one character he or she can root for.
3. Every character should want something, even if it is only a glass of water.
4. Every sentence must do one of two things—reveal character or advance the action.
5. Start as close to the end as possible.
6. Be a sadist. No matter how sweet and innocent your leading characters, make awful things happen to them—in order that the reader may see what they are made of.
7. Write to please just one person. If you open a window and make love to the world, so to speak, your story will get pneumonia.
8. Give your readers as much information as possible as soon as possible. To heck with suspense. Readers should have such complete understanding of what is going on, where and why, that they could finish the story themselves, should cockroaches eat the last few pages.

The greatest American short story writer of my generation was Flannery O'Connor (1925-1964). She broke practically every one of my rules but the first. Great writers tend to do that.
(From the preface to Vonnegut's short story collection Bagombo Snuff Box.)